![]() ![]() Cell-specific rescue of cam-1 and cell ablation experiments reveal a crucial role for the SIA and SIB neurons in positioning the nerve ring,linking Wnt signaling to specific cells that organize the anterior nervous system.Īlthough best known for their effects on embryonic patterning and cell fate, secreted Wnt proteins also direct cell and axon guidance along the anterior-posterior axis by acting as attractants or repellents( Fradkin et al., 2005). The identification of CAM-1 as a CWN-2 receptor contrasts with CAM-1 action as a non-receptor in other C. ![]() ![]() In nerve ring development, cwn-2 acts primarily through the Wnt receptor CAM-1 (Ror), together with the Frizzled protein MIG-1, with parallel roles for the Frizzled protein CFZ-2. cwn-2 is required at the time of nerve ring formation it is expressed by cells posterior of the nerve ring, but its precise site of expression is not critical for its function. In cwn-2 mutants, all neuronal structures in and around the nerve ring are shifted to an abnormal anterior position. elegans homolog of Wnt5, as a regulator of nerve ring placement. Here we demonstrate an essential role for Wnt signaling through Ror tyrosine kinase homologs in the most prominent anterior neuropil, the nerve ring. Wnt signaling through Frizzled proteins guides posterior cells and axons in C. ![]()
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